神经毒性评估的联合方法：新型非离子型造影剂的测试

Combined methods for assessment of neurotoxicity: testing of new nonionic radiographic media.

作者信息

Sovak M, Siefert H M, Ranganathan R

出版信息

Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S248-53. doi: 10.1097/00004424-198011001-00053.

DOI:10.1097/00004424-198011001-00053

PMID:7203930

Abstract

A battery of tests for toxicity assessment of new contrast media is reviewed. Cell toxicity in a protozoan culture (Blepharisma americanum); lethal dose determination in mice; EEG Spectral analysis following cisternography in rabbits; ED50 and LD50 determination by intra- and pericerebral injection in rats; intracisternal injection in chronically cannulated, nonanesthetized rats; and aversive conditioning by intracisternal injection in rats were found complementary. By these methods, novel nonionic media phenyl-sugar-ether DS-1-132 and DL-2-99 were found comparable to iopamidol, while all three compounds were superior to metrizamide.

摘要

综述了一组用于新型造影剂毒性评估的测试。包括原生动物培养（美洲裸藻）中的细胞毒性；小鼠的致死剂量测定；兔脑池造影后的脑电图频谱分析；大鼠脑内和脑周注射测定半数有效剂量（ED50）和半数致死剂量（LD50）；对长期插管、未麻醉大鼠进行脑池内注射；以及大鼠脑池内注射后的厌恶条件反射。发现这些方法具有互补性。通过这些方法，发现新型非离子型介质苯基糖醚DS-1-132和DL-2-99与碘帕醇相当，而这三种化合物均优于甲泛葡胺。