Luhn J P, Donath K, Haneke E
HNO. 1981 Jan;29(1):10-6.
The minor salivary glands of the lower lips were analyzed histologically and morphometrically from biopsy specimens taken from 29 patients with glossodynia and 12 normal controls. The causes of glossodynia included Sjögrens syndrome [5], stomatological disorders such as diabetes mellitus, prosthesis allergy, etc. [5], psychiatric depressions [6], and idiopathic [13]. Using semi-thin tissue sections, the following results were obtained: 1. The control group had an average acinous area of 70.2%. This area was moderately reduced in the older patient. In patients with glossdynia, the acinous area was reduced to a mean value of 38.9%. Some severe cases showed values of 10% and less. 2. The area of duct structures was 9.3% in control tissues, and increased to 13.1% in patients with glossodynia. Values to 26% were rarely observed. 3. The interstitial tissue of the control group was inconspicuous and contained only few inflammatory cells. In glossodynia, the reduction of glandular acini could be positively correlated with the proliferation of the connective tissue and to stromal infiltration by lymphocytes and plasma cells. In diffuse lymphocytic sialadenitis, the mean value of the acinous area was 46%. An additional focal lymphocytic infiltration resulted in a further reduction to 27.3%. 4. The most severe cases of sialadenitis were found in glossodynia associated with Sjögren's syndrome. As such, the lip biopsy was found to be a useful method for diagnosis of the syndrome.
对29例灼口综合征患者和12例正常对照者下唇小唾液腺活检标本进行组织学和形态计量学分析。灼口综合征的病因包括干燥综合征[5例]、口腔疾病如糖尿病、义齿过敏等[5例]、精神抑郁[6例]以及特发性[13例]。采用半薄组织切片，获得以下结果：1.对照组腺泡平均面积为70.2%。该面积在老年患者中适度减小。灼口综合征患者的腺泡面积减小至平均值38.9%。一些严重病例的值在10%及以下。2.对照组织中导管结构面积为9.3%，灼口综合征患者增加至13.1%。很少观察到高达26%的值。3.对照组间质组织不明显，仅含少量炎症细胞。在灼口综合征中，腺泡减少与结缔组织增生以及淋巴细胞和浆细胞的间质浸润呈正相关。在弥漫性淋巴细胞性涎腺炎中，腺泡面积平均值为46%。额外的局灶性淋巴细胞浸润导致进一步降至27.3%。4.涎腺炎最严重的病例见于与干燥综合征相关的灼口综合征。因此，唇活检被发现是诊断该综合征的一种有用方法。
