Wolkove N, Altose M D, Kelsen S G, Kondapalli P G, Cherniack N S
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jan;50(1):78-83. doi: 10.1152/jappl.1981.50.1.78.
Respiratory sensation was evaluated in normal subjects from their ability to quantitate changes in tidal volume. Subjects attempted to duplicate or double tidal volumes of different sizes while breathing freely or against a resistive or elastic load. When the mechanical conditions during control and test breaths were constant, tidal volume duplication was accomplished with an error of approximately 100 ml, regardless of the control volume. The error in doubling, however, increased progressively with increasing control tidal volume. There was a greater error in both volume duplication and doubling when the mechanical conditions between control and test breaths were changed. When test breaths against a load followed unloaded control breaths, tidal volume failed to double, but intrathoracic pressure changes twice exceeded control values. Conversely, when unloaded test breaths followed loaded control breaths, pressure changes underwent less than a twofold increase while tidal volume more than doubled. The results indicate that tidal volume changes are normally sensed with considerable accuracy and suggest that both tidal volume per se, as well as the forces generated by the respiratory muscles, are used in the estimation of tidal volume changes.
通过正常受试者定量潮气量变化的能力来评估呼吸感觉。受试者在自由呼吸或对抗阻力或弹性负荷时，试图复制或加倍不同大小的潮气量。当对照呼吸和测试呼吸期间的机械条件恒定时，无论对照气量如何，潮气量复制的误差约为100毫升。然而，加倍的误差随着对照潮气量的增加而逐渐增加。当对照呼吸和测试呼吸之间的机械条件改变时，气量复制和加倍的误差都更大。当对抗负荷的测试呼吸跟随无负荷的对照呼吸时，潮气量未能加倍，但胸内压变化两倍超过对照值。相反，当无负荷的测试呼吸跟随有负荷的对照呼吸时，压力变化增加不到两倍，而潮气量增加超过两倍。结果表明，潮气量变化通常能被相当准确地感知，并表明潮气量本身以及呼吸肌产生的力量都被用于估计潮气量变化。
