孕期血浆胰多肽水平降低。

Decreased plasma pancreatic polypeptide levels in pregnancy.

作者信息

Hornnes P J, Kühl C

出版信息

J Clin Endocrinol Metab. 1981 Apr;52(4):605-7. doi: 10.1210/jcem-52-4-605.

PMID:7204535

Abstract

The pancreatic polypeptide (PP) response to oral glucose ingestion was determined in late pregnancy and post partum in 11 normal healthy women. Glucose tolerance was significantly impaired in pregnancy compared to post partum. Fasting plasma PP concentrations were reduced in pregnancy [7.6 +/- 1.2 vs. 12.6 +/- 1.2 pmol liter-1 (mean +/0- SE); P less than 0.01]. The levels of PP increased after glucose ingestion during pregnancy as well as post partum, but the PP response was significantly impaired in gestation (integrated PP responses: 548 +/- 331 vs. 1645 +/- 347 pmol liter-1 min-1; P less than 0.01). It is concluded that in pregnancy, PP levels after an overnight fast are decreased and the PP response to glucose is diminished compared to post partum.

摘要

对11名正常健康女性在妊娠晚期和产后口服葡萄糖后的胰多肽（PP）反应进行了测定。与产后相比，妊娠期糖耐量显著受损。妊娠期空腹血浆PP浓度降低[7.6±1.2 vs. 12.6±1.2 pmol·升⁻¹（均值±标准误）；P<0.01]。妊娠期和产后葡萄糖摄入后PP水平均升高，但妊娠期PP反应显著受损（PP综合反应：548±331 vs. 1645±347 pmol·升⁻¹·分钟⁻¹；P<0.01）。结论是，与产后相比，妊娠期经过一夜禁食后PP水平降低，且对葡萄糖的PP反应减弱。