Baden H P, Kubilus J
J Am Acad Dermatol. 1980 Dec;3(6):623-6. doi: 10.1016/s0190-9622(80)80078-8.
Two patients with alopecia congenita had short vellus hairs of the scalp but some apparently normal-sized hairs in other areas. Both fibrous and matrix proteins were detected in the scalp hairs by polyacrylamide gel electrophoresis (PAGE), and x-ray diffraction analysis revealed a normal alpha pattern. Amino acid analysis showed a decreased cystine content suggesting a quantitative or qualitative change in the matrix component. Scanning electron microscopic examination revealed pits and bulges in the cuticle cells which may be related to wearing a wig. The data suggest a defect in the development of the follicle rather than an abnormality in a component of the hair.
两名先天性脱发患者头皮上有短的毳毛，但其他部位有一些明显正常大小的毛发。通过聚丙烯酰胺凝胶电泳（PAGE）在头皮毛发中检测到纤维蛋白和基质蛋白，X射线衍射分析显示出正常的α模式。氨基酸分析表明胱氨酸含量降低，提示基质成分存在定量或定性变化。扫描电子显微镜检查发现角质形成细胞中有凹坑和凸起，这可能与戴假发有关。数据表明毛囊发育存在缺陷，而非毛发成分异常。
