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拉伸肌肉纤维中横桥滑动的证据。

Evidence for cross bridge slippage in a stretched muscle fibre.

作者信息

Güth K, Kuhn H J, Herzig J W, Rüegg J C

出版信息

Experientia. 1978 Sep 15;34(9):1183-4. doi: 10.1007/BF01922946.

DOI:10.1007/BF01922946
PMID:720517
Abstract

Bundles of glycerol-extracted psoas fibres which were contracted by immersion in a saline containing 15 mM MgATP and 12 micron free Ca++ were subjected to up to 3 stretches (rise time 0.8 msec) each of amplitude 1% Li at intervals of 10 msec. The elastic tension responses to these stretches were all of comparable size and the peak tensions reached during the stretches were in each case followed by a rapid tension decline almost to the tension values before the stretches. This indicates that stretch-induced detachment and reattachment of cross bridges to the actin filament occurred within 10 msec (slippage).

摘要

将浸于含有15 mM 镁三磷酸腺苷(MgATP)和12微摩尔游离钙离子(Ca++)的盐溶液中而收缩的甘油抽提腰大肌纤维束,每隔10毫秒进行高达3次的拉伸(上升时间0.8毫秒),每次拉伸幅度为1%的长度变化(Li)。对这些拉伸的弹性张力反应大小都相当,并且在每次拉伸过程中达到的峰值张力之后,紧接着是张力迅速下降,几乎降至拉伸前的张力值。这表明,在10毫秒内发生了拉伸诱导的横桥与肌动蛋白丝的分离和重新附着(滑动)。

相似文献

1
Evidence for cross bridge slippage in a stretched muscle fibre.拉伸肌肉纤维中横桥滑动的证据。
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2
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引用本文的文献

1
Cross bridge slippage in skinned frog muscle fibres.剥制蛙肌纤维中的横桥滑动
Biophys Struct Mech. 1980;7(2):107-24. doi: 10.1007/BF00538402.
2
The effect of inorganic phosphate on the ATP hydrolysis rate and the tension transients in chemically skinned rabbit psoas fibers.无机磷酸盐对化学去膜兔腰大肌纤维中ATP水解速率和张力瞬变的影响。
Pflugers Arch. 1987 Jan;408(1):1-9. doi: 10.1007/BF00581833.
3
Force response to rapid length change during contraction and rigor in skinned smooth muscle of guinea-pig taenia coli.豚鼠结肠带皮平滑肌收缩和强直状态下对快速长度变化的力反应。

本文引用的文献

1
Muscle structure and theories of contraction.肌肉结构与收缩理论。
Prog Biophys Biophys Chem. 1957;7:255-318.
2
Induced changes in orientation of the cross-bridges of glycerinated insect flight muscle.甘油处理的昆虫飞行肌横桥取向的诱导变化。
Nature. 1965 Sep 18;207(5003):1276-80. doi: 10.1038/2071276a0.
3
A model for the transient and steady-state mechanical behavior of contracting muscle.一种收缩肌肉瞬态和稳态力学行为的模型。
J Physiol. 1991 Oct;442:601-30. doi: 10.1113/jphysiol.1991.sp018811.
4
Stiffness and tension during and after sudden length changes of glycerinated single insect fibrillar muscle fibres.甘油处理的单个昆虫肌原纤维在突然长度变化期间及之后的刚度和张力。
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The mechanism of muscular contraction.肌肉收缩的机制。
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Energetics and mechanism of actomyosin adenosine triphosphatase.肌动球蛋白三磷酸腺苷酶的能量学与机制
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