Julian F J, Sollins K R, Sollins M R
Biophys J. 1974 Jul;14(7):546-62. doi: 10.1016/S0006-3495(74)85934-5.
A model was developed which can simulate both the transient and steady-state mechanical behavior of contracting skeletal striated muscle. Thick filament cross-bridges undergo cycles of attachment to and detachment from thin filament sites. Cross-bridges can attach only while in the first of two stable states. Force is then generated by a transition to the second state after which detachment can occur. Cross-bridges are assumed to be connected to the thin filaments by an elastic element whose extension or compression influences the rate constants for attachment, detachment, and changes between states. The model was programmed for a digital computer and attempts made to match both the transient and the steady-state responses of the model to that of real muscle in two basic types of experiment: force response to sudden change in length and length response to sudden reduction of load from P(o). Values for rate constants and other parameters were chosen to try to match the model's output to results from real muscles, while at the same time trying to accommodate structural and biochemical information.
开发了一种模型，该模型可以模拟收缩的骨骼肌横纹肌的瞬态和稳态力学行为。粗肌丝横桥经历与细肌丝位点附着和脱离的循环。横桥仅在两种稳定状态中的第一种状态时才能附着。然后通过转变到第二种状态产生力，之后可能发生脱离。假设横桥通过一个弹性元件连接到细肌丝，该弹性元件的伸展或压缩会影响附着、脱离以及状态之间变化的速率常数。该模型已针对数字计算机进行编程，并在两种基本类型的实验中尝试使模型的瞬态和稳态响应与真实肌肉的响应相匹配：长度突然变化时的力响应以及从P（o）突然降低负荷时的长度响应。选择速率常数和其他参数的值，试图使模型的输出与真实肌肉的结果相匹配，同时尝试纳入结构和生化信息。
