Gillman M A, Lichtigfeld F J
J Neurol Sci. 1981 Jan;49(1):41-5. doi: 10.1016/0022-510x(81)90186-6.
The effect of nitrous oxide and morphine sulphate on chronic pain states in man are compared. The similarity of effect indicate that nitrous oxide acts on the morphine receptor. In all cases where analgesia was produced naloxone reversal occurred. These results provide additional evidence for a dual system hypothesis of pain perception and that nitrous oxide analgesia is mediated by the endogenous opiate system. In the light of these findings, the possibility of using nitrous oxide to replace morphine sulphate as a screening test for deep brain stimulation analgesia is discussed.
比较了一氧化二氮和硫酸吗啡对人类慢性疼痛状态的影响。效果的相似性表明一氧化二氮作用于吗啡受体。在所有产生镇痛作用的情况下，纳洛酮均可逆转。这些结果为疼痛感知的双系统假说提供了额外证据，且一氧化二氮镇痛是由内源性阿片系统介导的。鉴于这些发现，讨论了使用一氧化二氮替代硫酸吗啡作为深部脑刺激镇痛筛查试验的可能性。
