Fosburg M T, Crone R K
JAMA. 1983;250(4):511-3.
Nitrous oxide analgesia was used in the management of the terminal hospitalization of four adolescents and one child with disseminated cancer. All patients had severe pain that was unresponsive to standard regimens of narcotics and various narcotic analgesia-stimulant combinations. In each case, the addition of nitrous oxide led to an obvious improvement in symptoms of pain, anxiety, and agitation, while simultaneously improving appetite, mood, and the capacity to communicate. There were no side effects except those related to the discomfort of wearing a mask. Acceptance of the procedure by patient, family, and staff was universal and enthusiastic. The procedure is safe, easily administered, and noninvasive. Nitrous oxide can be useful in managing terminal illness refractory to standard pain control measures.
氧化亚氮镇痛法用于治疗四名青少年和一名患有播散性癌症儿童的临终住院治疗。所有患者均有严重疼痛，对标准麻醉方案及各种麻醉镇痛-兴奋剂联合用药均无反应。在每种情况下，添加氧化亚氮均使疼痛、焦虑和烦躁症状明显改善，同时改善了食欲、情绪和沟通能力。除了与佩戴面罩不适相关的副作用外，没有其他副作用。患者、家属和工作人员对该方法普遍接受且热情。该方法安全、易于实施且无创。氧化亚氮可用于治疗对标准疼痛控制措施无效的晚期疾病。
