阿扑吗啡-氟哌啶醇相互作用：皮质和皮质下脑区不同类型的拮抗作用。

Apomorphine-haloperidol interactions: different types of antagonism in cortical and subcortical brain regions.

作者信息

Bacopoulos N G, Roth R H

出版信息

Brain Res. 1981 Feb 2;205(2):313-9. doi: 10.1016/0006-8993(81)90342-5.

DOI:10.1016/0006-8993(81)90342-5

Abstract

Apomorphine, a dopamine (DA) receptor stimulant induced a dose-dependent decrease in the content of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the olfactory tubercle and striatum of rats, but it was ineffective in the frontal cortex. Apomorphine also antagonized the haloperidol-induced accumulation of DOPAC and HAV in the olfactory tubercle and striatum, whereas in the frontal cortex it antagonized the effects of haloperidol on DOPAC but not on HVA. The total (free and conjugated) content of DA metabolites was measured in these experiments.

摘要

阿扑吗啡，一种多巴胺（DA）受体兴奋剂，可使大鼠嗅结节和纹状体中多巴胺代谢产物3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）的含量呈剂量依赖性降低，但对额叶皮质无效。阿扑吗啡还拮抗氟哌啶醇诱导的嗅结节和纹状体中DOPAC和HAV的蓄积，而在额叶皮质中，它拮抗氟哌啶醇对DOPAC的作用，但不拮抗对HVA的作用。这些实验中测定了DA代谢产物的总（游离和结合）含量。

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