结缔组织激活 十九. 类风湿关节炎中血小板抗原CTAP-III的血浆水平
Connective tissue activation XIX. Plasma levels of the CTAP-III platelet antigen in rheumatoid arthritis.
作者信息
Myers S L, Hossler P A, Castor C W
出版信息
J Rheumatol. 1980 Nov-Dec;7(6):814-9.
Plasma levels of platelet granule proteins CTAP-III and beta-thromboglobulin (beta-TG) were measured by radioimmunoassay of their common antigen (CTAP-Ag). Healthy adults had 29.4 +r5.8 ng CTAP-Ag/ml plasma while patients with rheumatoid arthritis (RA) had higher levels of the CTAP-Ag (range 23-260 ng/ml, median 43 ng/ml, p less than .006). RA patients with CTAP-Ag levels greater than 50 ng/ml (mean 104.8 ng/ml) were compared to patients having lower CTAP-Ag levels. Patients in the group with elevated plasma CTAP-Ag levels had higher sedimentation rates (p less than .005), and higher platelet counts (p less than .05). Anemia was more common in patients with abnormal CTAP-Ag levels.
通过对血小板颗粒蛋白CTAP-III和β-血小板球蛋白（β-TG）的共同抗原（CTAP-Ag）进行放射免疫测定，来检测血浆中这些蛋白的水平。健康成年人血浆中CTAP-Ag的水平为29.4±5.8 ng/ml，而类风湿性关节炎（RA）患者的CTAP-Ag水平较高（范围为23 - 260 ng/ml，中位数为43 ng/ml，p<0.006）。将CTAP-Ag水平大于50 ng/ml（平均104.8 ng/ml）的RA患者与CTAP-Ag水平较低的患者进行比较。血浆CTAP-Ag水平升高组的患者血沉率更高（p<0.005），血小板计数也更高（p<0.05）。CTAP-Ag水平异常的患者中贫血更为常见。
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