柠檬酸盐琼脂电泳在抗镰状化剂评估中的应用。

Wilson E, Winter W P

J Natl Med Assoc. 1981 Feb;73(2):111-6.

Hemoglobin S (Hb S), treated with antisickling agents which interfere with gel formation, has been found to migrate on citrate agar electrophoresis in a manner similar to Hb A or Hb F. This finding suggests a rapid and inexpensive method for screening potential antisickling compounds of the types which interfere with gelation. This investigation has also led to an improved understanding of the molecular basis of citrate agar electrophoresis and to the realization that agar itself may contain a natural antisickling agent.

用干扰凝胶形成的抗镰状化剂处理过的血红蛋白S（Hb S），已发现在柠檬酸盐琼脂电泳中迁移方式与Hb A或Hb F相似。这一发现提示了一种快速且廉价的方法，用于筛选干扰凝胶化类型的潜在抗镰状化化合物。这项研究还增进了对柠檬酸盐琼脂电泳分子基础的理解，并认识到琼脂本身可能含有一种天然抗镰状化剂。