Lieber M M, Tomera F M, Taylor W F, Farrow G M
J Urol. 1981 Feb;125(2):164-8. doi: 10.1016/s0022-5347(17)54948-4.
Survival rates and various prognostic factors were studied in 89 patients between 20 and 40 years old who underwent nephrectomy for renal adenocarcinoma between 1950 and 1978. Although rare, renal carcinoma in young adults seems to follow a course similar to the disease seen in older patients. Among 18 suspected prognostic factors 2 are strongly and independently associated with survival. These are the pathologic stage of the tumor and preoperative weight loss. Several other prognostic variables show a statistically significant association with survival. These include the presence of preoperative fever, duration of symptoms, tumor cell type, microhematuria on admission to the hospital, tumor grade and sex. However, advanced statistical techniques demonstrate that the association of these variables with survival can be accounted for mostly by their close correlation with the stage of the tumor. Certain variables show no prognostic significance. These included the diameter of the tumor, age of the patient, presence or absence of gross hematuria, flank pain, palpable mass, arterial hypertension, sedimentation rate and side or site of the tumor.
对1950年至1978年间因肾腺癌接受肾切除术的89例20至40岁患者的生存率和各种预后因素进行了研究。虽然在年轻人中肾癌很少见，但似乎其病程与老年患者的疾病相似。在18个疑似预后因素中，有2个与生存率密切且独立相关。这两个因素是肿瘤的病理分期和术前体重减轻。其他几个预后变量与生存率有统计学上的显著关联。这些因素包括术前发热、症状持续时间、肿瘤细胞类型、入院时镜下血尿、肿瘤分级和性别。然而，先进的统计技术表明，这些变量与生存率的关联大多可归因于它们与肿瘤分期的密切相关性。某些变量没有预后意义。这些变量包括肿瘤直径、患者年龄、肉眼血尿的有无、胁腹痛、可触及肿块、动脉高血压、血沉率以及肿瘤的侧别或部位。
