Chodak G W, Straus F W, Schoenberg H W
J Urol. 1981 Mar;125(3):424-6. doi: 10.1016/s0022-5347(17)55061-2.
We report on a patient who had a urothelial tumor with tri-differentiation into transitional squamous and adenocarcinoma after ingestion of 285 gm. cyclophosphamide during a 15-year-period. The possibility is again raised that the use of high doses of this drug over long periods may be associated with an increased incidence of carcinoma of the bladder. Frequent cystoscopic examinations may be warranted in patients who have received large cumulative amounts of the drug
我们报告了一名患者，该患者在15年期间摄入285克环磷酰胺后发生了具有移行、鳞状和腺癌三重分化的尿路上皮肿瘤。长期使用高剂量这种药物可能与膀胱癌发病率增加相关的可能性再次被提出。对于接受了大量累积剂量该药物的患者，可能有必要进行频繁的膀胱镜检查。
