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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nakanomyo H, Imai K, Hiraoka M, Hasegawa Y

Jpn J Antibiot. 1980 Aug;33(8):773-7.

Human serum protein binding of cefadroxil and some other cephalosporins were determined by centrifugal ultrafiltration (U.F.) method and equilibrium dialysis (E.D.) method. The binding rates of cefadroxil were 28.1% by U.F. method and 3.8% (beta 1*), 11.6% (beta 2*) by E.D. method. 2. Protein binding of cefadroxil with sera of various animal species were also determined by E.D. method. The binding rates were low as well as that with human serum. 3. With two popular calculation formula for E.D. method, binding rate was considered on the alteration of the ratio of V2/V1.

采用离心超滤（U.F.）法和平衡透析（E.D.）法测定了头孢羟氨苄与人血清蛋白的结合率以及其他一些头孢菌素与人血清蛋白的结合率。通过超滤法测得头孢羟氨苄的结合率为28.1%，通过平衡透析法测得其结合率为3.8%（β1*）、11.6%（β2*）。2. 还采用平衡透析法测定了头孢羟氨苄与不同动物物种血清的蛋白结合率。其结合率与在人血清中的结合率一样低。3. 对于平衡透析法的两个常用计算公式，结合率是根据V2/V1比值的变化来考虑的。

Nakanomyo H, Imai K, Hiraoka M, Hasegawa Y

Jpn J Antibiot. 1980 Aug;33(8):773-7.

Human serum protein binding of cefadroxil and some other cephalosporins were determined by centrifugal ultrafiltration (U.F.) method and equilibrium dialysis (E.D.) method. The binding rates of cefadroxil were 28.1% by U.F. method and 3.8% (beta 1*), 11.6% (beta 2*) by E.D. method. 2. Protein binding of cefadroxil with sera of various animal species were also determined by E.D. method. The binding rates were low as well as that with human serum. 3. With two popular calculation formula for E.D. method, binding rate was considered on the alteration of the ratio of V2/V1.

采用离心超滤（U.F.）法和平衡透析（E.D.）法测定了头孢羟氨苄与人血清蛋白的结合率以及其他一些头孢菌素与人血清蛋白的结合率。通过超滤法测得头孢羟氨苄的结合率为28.1%，通过平衡透析法测得其结合率为3.8%（β1*）、11.6%（β2*）。2. 还采用平衡透析法测定了头孢羟氨苄与不同动物物种血清的蛋白结合率。其结合率与在人血清中的结合率一样低。3. 对于平衡透析法的两个常用计算公式，结合率是根据V2/V1比值的变化来考虑的。