Goldberg A P, Hagberg J M, Delmez J A, Haynes M E, Harter H R
Kidney Int. 1980 Dec;18(6):754-61. doi: 10.1038/ki.1980.194.
The effects of 9 +/- 6 months of exercise training on lipid and carbohydrate metabolism were studied in six hemodialysis patients. Training lowered triglyceride levels 39 +/- 25% (P less than 0.02) and increased plasma high-density lipoprotein cholesterol levels 23 +/- 22% (before, 26 +/- 5 mg/dl; after, 31 +/- 8 mg/dl; P less than 0.05). There was a 23% improvement in glucose tolerance (P less than 0.01) and a 40% reduction in hyperinsulinism (P less than 0.01) with no significant changes in body weight or diet. There was a 25 +/- 8% increase in hematocrits (before, 22 +/- 2%; after, 27 +/- 2%, P less than 0.01) and a 29 +/- 2% rise in hemoglobin concentrations (before, 7.0 +/- 0.8 g/dl; after, 9.0 +/- 0.6 g/dl, P less than 0.04) in five patients. In addition, during training antihypertensive medications could be reduced in three patients with maintenance of normal blood pressure. The improvements in lipid and carbohydrate metabolism diminished when two patients stopped training. These results suggest that physical training can improve some of the metabolic abnormalities observed in hemodialysis patients and could be important as a therapeutic modality.
对6名血液透析患者进行了9±6个月运动训练对脂质和碳水化合物代谢影响的研究。训练使甘油三酯水平降低了39±25%（P<0.02），血浆高密度脂蛋白胆固醇水平升高了23±22%（训练前为26±5mg/dl；训练后为31±8mg/dl；P<0.05）。葡萄糖耐量提高了23%（P<0.01），高胰岛素血症降低了40%（P<0.01），而体重和饮食无显著变化。5名患者的血细胞比容增加了25±8%（训练前为22±2%；训练后为27±2%，P<0.01），血红蛋白浓度升高了29±2%（训练前为7.0±0.8g/dl；训练后为9.0±0.6g/dl，P<0.04）。此外，在训练期间，3名患者在维持正常血压的情况下可减少抗高血压药物的使用。当2名患者停止训练时，脂质和碳水化合物代谢的改善减弱。这些结果表明，体育锻炼可以改善血液透析患者中观察到的一些代谢异常，并且作为一种治疗方式可能很重要。
