Rolstad B
Lymphology. 1980 Dec;13(4):197-201.
The effect of humoral factors released during systemic graft-versus-host (GVH) reactions on cell proliferation and lymph node enlargement was investigated as follows: 1) Thoracic duct lymphocytes of host origin were cultured in diffusion chambers in the peritoneal cavity of rats undergoing a systemic GVH reaction. On day 7 of the response chamber cell proliferation (as judged by 3H thymidine incorporation) was increased two to four fold over that seen in normal hosts. 2) Serum from (H0 x DA) F1 hybrid rats being repeatedly injected with parental (HO) cells contained a factor that, when preincubated with such parental cells in vitro, was able to augment their ability to produce lymph node enlargement in a local GVH reaction. These results suggest that the host cell proliferation and lymphoid hyperplasia observed during GVH reactions might be the results of long range humoral mechanisms acting alone or in addition to the direct interaction between donor and host cells.
对全身移植物抗宿主（GVH）反应期间释放的体液因子对细胞增殖和淋巴结肿大的影响进行了如下研究：1）将宿主来源的胸导管淋巴细胞培养于正在经历全身GVH反应的大鼠腹腔内的扩散小室中。在反应的第7天，小室细胞增殖（通过3H胸苷掺入判断）比正常宿主增加了2至4倍。2）反复注射亲代（H0）细胞的（H0×DA）F1杂种大鼠的血清含有一种因子，当在体外与这种亲代细胞预孵育时，能够增强它们在局部GVH反应中产生淋巴结肿大的能力。这些结果表明，在GVH反应期间观察到的宿主细胞增殖和淋巴组织增生可能是单独起作用的远距离体液机制的结果，或者是除了供体和宿主细胞之间的直接相互作用之外的结果。
