用SKF 525A预处理后，氯吉兰对大鼠肝脏单胺氧化酶-A抑制作用的增强。
Potentiation of the inhibition of rat liver monoamine oxidase-a by clorgyline after pretreatment with SKF 525A.
作者信息
Fowler C J
出版信息
Med Biol. 1980 Oct;58(5):285-7.
PMID:7206835
Abstract
Pretreatment of rat liver homogenates with 1.5 x 10(-4) M SKF 525A is without effect on the activity of monoamine oxidase-A, but results in a decrease in the concentration of clorgyline required for the inhibition of this enzyme form. Such a result is consistent with the hypothesis that rat liver homogenates contain an SKF 525A-sensitive clorgyline-metabolising system.
摘要
用1.5×10⁻⁴ M的SKF 525A预处理大鼠肝脏匀浆，对单胺氧化酶-A的活性没有影响，但会导致抑制这种酶形式所需的氯吉兰浓度降低。这样的结果与大鼠肝脏匀浆含有对SKF 525A敏感的氯吉兰代谢系统这一假设相一致。
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