Esteban R, Vargas V, Pedreira J D, Allende E, Guardia J, Bacardí R
Med Clin (Barc). 1981 Feb 25;76(4):172-5.
Although acute alcoholic hepatitis is a frequent disease with distinct histologic diagnosis, the prognostic factors of its evolution are largely unknown. The present report analyzes the data of 18 patients with acute alcoholic liver disease submitted to two liver biopsies with a mean interval of 35 months. The results demonstrate a favorable histologic evolution in six of seven patients that abandoned alcohol ingestion, and an evolution to chronic liver disease in the remaining case. Out of six patients with continuous alcohol ingestion the evolution was unfavorable in five, while one case evolved to healing. Centrilobular fibrosis disappeared in the six cases that discontinued alcohol ingestion and who had favorable evolution, and it persisted in four of the six patients that continued drinking. The results suggest that centrilobular fibrosis is not always an unfavorable prognostic marker, and that the evolution of acute alcoholic hepatitis is not exclusively dependent on the continuation of alcohol abuse.
尽管急性酒精性肝炎是一种常见疾病，有明确的组织学诊断，但其病情演变的预后因素在很大程度上尚不清楚。本报告分析了18例急性酒精性肝病患者的数据，这些患者接受了两次肝活检，平均间隔35个月。结果显示，7例戒酒患者中有6例组织学演变良好，其余1例演变为慢性肝病。在6例持续饮酒的患者中，5例病情演变不利，1例病情好转。在6例戒酒且病情演变良好的患者中，小叶中心纤维化消失；在6例继续饮酒的患者中，有4例小叶中心纤维化持续存在。结果表明，小叶中心纤维化并不总是不良预后指标，急性酒精性肝炎的演变并非完全取决于持续酗酒。
