González Maqueda I, García Fernández F, Martín Jadraque L
Med Clin (Barc). 1981 Mar 10;76(5):223-5.
Electrophysiologic studies have been performed in 11 patients before and 12 minutes after intravenous administration of 250 mg of mexiletine. All patients had crisis of paroxysmal tachycardia. The cases with conduction defects at any level, as ascertained by surface ECG or basal electrophysiologic recordings, were excluded from treatment. The results obtained do not show significant variations in any of the parameters studied. It is concluded that mexiletine is an antiarrhythmic drug with an action typical of group I of the classification of Vaughan Williams, and that it reduces the maximum velocity of systolic depolarization. In the absence of conduction defects, its behaviour is similar to that of lidocaine or diphenylhydantoin.
对11例患者在静脉注射250毫克美西律之前及之后12分钟进行了电生理研究。所有患者均有阵发性心动过速发作。通过体表心电图或基础电生理记录确定存在任何程度传导缺陷的病例被排除在治疗之外。所获得的结果表明，在研究的任何参数中均未显示出显著变化。结论是，美西律是一种具有 Vaughan Williams 分类中I类典型作用的抗心律失常药物，它降低了收缩期去极化的最大速度。在没有传导缺陷的情况下，其表现与利多卡因或苯妥英钠相似。
