Revuz J, Touraine R
Dermatologica. 1978;157(6):377-85.
Woringer and Kolopp's disease is a rare skin disease. Erythemato-squamous, slightly infiltrated lesions with round-shaped islets of normal skin are the clinical hall-marks of the disease. The histological picture is highly specific: a dense epidermal infiltrate disrupts the stratum spinosum, contrasting with a spared dermis. Three different aspects of the disease have been reported: a localized benign type as in Woringer and Kolopp's patient; a disseminated lethal type without visceral involvement and without preexisting lesions, and a disseminated lethal type in which lesions appear on erythematous patches clinically and histologically similar to "parapsoriasis en plaques". It is the opinion of the authors that the third type is not Woringer and Kolopp's disease but an extremely epidermotropic variant of mycosis fungoides. The two other types seem to be variants of the same disease. Several hypotheses about the nature of that disorder are discussed. Most authors think that Woringer and Kolopp's disease is a cutaneous lymphoma because of clinical, histological and ultrastructural similarities with mycosis fungoides. We are presenting evidence favoring the hypothesis of a Merkel cell proliferative disease.
沃林格-科洛普病是一种罕见的皮肤病。红斑鳞屑性、轻度浸润性皮损伴有圆形正常皮肤小岛是该病的临床特征。组织学表现具有高度特异性：致密的表皮浸润破坏棘层，与未受累的真皮形成对比。该病已报道有三种不同表现：如沃林格和科洛普病例中的局限性良性型；无内脏受累且无既往病变的播散性致死型；以及皮损在临床上和组织学上表现为类似“斑块状副银屑病”的红斑上出现的播散性致死型。作者认为第三种类型并非沃林格-科洛普病，而是蕈样肉芽肿的一种极度亲表皮变体。另外两种类型似乎是同一疾病的变体。文中讨论了关于该疾病本质的几种假说。大多数作者认为沃林格-科洛普病是一种皮肤淋巴瘤，因为其在临床、组织学和超微结构上与蕈样肉芽肿相似。我们正在提供支持默克尔细胞增殖性疾病假说的证据。
