Geerts M L, Kaiserling E, Kint A
Dermatologica. 1982 Jan;164(1):15-29. doi: 10.1159/000250061.
A localized form of 'Pagetoid reticulosis' (Woringer-Kolopp's disease) is described morphologically. It can be shown that ultrastructurally the 'Pagetoid cells' are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans' cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans' cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp's disease seems to build up the specific microenvironment for lymphoid cell reaction.
本文从形态学角度描述了“派杰样网状细胞增生症”（沃林格－科洛普病）的一种局限性形式。超微结构研究表明，“派杰样细胞”具有异质性，可区分出不同的细胞类型：有常类似卢茨纳细胞的淋巴细胞，以及可被界定为不定形细胞或朗格汉斯细胞的非淋巴细胞。淋巴细胞与非淋巴细胞之间常可见紧密的局部关系。这一发现提示，极有可能为T细胞的淋巴细胞与已知在胸腺依赖性免疫反应中起重要作用的不定形细胞及朗格汉斯细胞之间存在功能相互作用。沃林格－科洛普病表皮中非淋巴细胞群的存在似乎为淋巴细胞反应构建了特定的微环境。
