Blanc M H, Rhie F H, Dunn P J, Soeldner J S
Metabolism. 1981 Apr;30(4):317-22. doi: 10.1016/0026-0495(81)90108-6.
Glycosylated hemoglobins (GHb) or fast hemoglobins (FH) are minor components of hemoglobin that so far have been quantified in men, monkeys, and mice, and they are elevated in diabetic subjects of all these species. Since the rat is a useful model for experimental diabetic studies, hemolysates from streptozotocin-induced diabetic rats were analyzed for FH fractions using a high pressure liquid chromatography method. In a long-term study (3 mo), the maximal increment of the FH fractions was achieved after 5 wk of diabetes (from 5.67% +/- 0.41% SD to 10.80% +/- 0.74%) supporting the notion that the biosynthesis of these compounds occurs continuously during the lifespan of the red cell. In a short-term study, however, an elevation of the FH by 11% after 2 days and by 26% after 6 days of diabetes was noticed suggesting that a rapid increase of the FH may occur in relation to rapid changes of the glucose level.
糖化血红蛋白（GHb）或快速血红蛋白（FH）是血红蛋白的次要成分，目前已在人类、猴子和小鼠中进行了定量分析，并且在所有这些物种的糖尿病患者中其含量都会升高。由于大鼠是实验性糖尿病研究的有用模型，因此使用高压液相色谱法分析了链脲佐菌素诱导的糖尿病大鼠的溶血产物中的FH组分。在一项长期研究（3个月）中，糖尿病5周后FH组分达到最大增量（从5.67%±0.41%标准差增至10.80%±0.74%），这支持了这些化合物的生物合成在红细胞寿命期间持续发生的观点。然而，在一项短期研究中，发现糖尿病2天后FH升高11%，6天后升高26%，这表明FH可能会随着血糖水平的快速变化而迅速增加。
