Scolozzi R, Boccafogli A, Romanini D, Ramazzina E, Careri C, Guidoboni C A
Minerva Med. 1981 Feb 18;72(4-5):205-11.
Forty-seven consecutive patients with chronic lymphocytic leukemia (CLL) followed in the Clinica Medica and the Sezione di Ematologia of Ferrara from January 1966 to June 1979 were classified according to the staging system of Rai and to age, sex and the occurrence of enlarged spleen or liver or both. Analysis of actuarial survival curves revealed the following: 1) the method of staging proposed by Rai was confirmed to be a reliable predictor for prognosis of CLL; 2( neither age nor sex do appear to be prognostic factor; 3) the enlarged liver did not appear to make worse the prognosis of CLL, probably by hepatomegalies due to other aetiologies. Furthermore the bound of peripheral lymphocytosis of 15,000/mm3, also according to other authors, seems to be too high: numerous cases of undoubted CLL with smaller lymphocytosis ae left out of this and other statistics published on CLL.
1966年1月至1979年6月期间，在费拉拉临床医学院和血液科接受随访的47例连续性慢性淋巴细胞白血病（CLL）患者，根据Rai分期系统以及年龄、性别和脾脏或肝脏肿大或两者皆有的情况进行分类。精算生存曲线分析显示如下：1）Rai提出的分期方法被证实是CLL预后的可靠预测指标；2）年龄和性别似乎都不是预后因素；3）肝脏肿大似乎并未使CLL的预后变差，可能是由于其他病因导致的肝肿大。此外，外周淋巴细胞增多症的界限为15,000/mm³，根据其他作者的研究，这一界限似乎过高：许多淋巴细胞增多症较小但无疑为CLL的病例被排除在关于CLL的此类及其他统计数据之外。
