Young J A, Maruyama Y
Oncology. 1981;38(3):138-43. doi: 10.1159/000225540.
An in vitro system was used to study the uptake of 5-fluorouracil by LSA ascites tumor cells. Changes in drug uptake with cell age and following a 1,000-rad radiation perturbation of the cell population were studied. DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with tumor age and stationary phase. Radiation perturbation by 1,000 rad caused a second peak of cellular DNA synthetic activity and drug uptake. These results indicate that irradiation stimulated regrowth activity of tumor in vivo after the 1,000-rad exposure. In vivo survival time changes of stationary phase tumor after in vivo irradiation correlated with the vitro assay data. This indicates that combined treatment modalities depends in part on the regrowth of tumor after tumor cell killing.
利用体外系统研究LSA腹水肿瘤细胞对5-氟尿嘧啶的摄取。研究了随着细胞年龄以及在对细胞群体进行1000拉德辐射扰动后药物摄取的变化。DNA合成和药物摄取在肿瘤早期快速生长期间最高，并随着肿瘤年龄和静止期而降低。1000拉德的辐射扰动导致细胞DNA合成活性和药物摄取出现第二个峰值。这些结果表明，1000拉德照射后，体内肿瘤的再生长活性受到刺激。体内照射后静止期肿瘤的体内存活时间变化与体外测定数据相关。这表明联合治疗方式部分取决于肿瘤细胞杀伤后肿瘤的再生长。
