Young J A, Maruyama Y
Radiology. 1982 Mar;142(3):759-63. doi: 10.1148/radiology.142.3.7063699.
An in vitro system was used to assess uptake of cytosine arabinoside by LSA ascites tumor cells growing in vivo. Changes in tumor uptake with aging after depopulation and perturbation of the cell population with 1,000 rad were studied. Both DNA synthesis and drug uptake were highest during early rapid tumor growth and decreased with aging and the stationary phase of growth. However, irradiation caused a second peak of cellular activity and drug uptake. These results indicate that irradiation stimulates regrowth of tumor.
使用体外系统评估体内生长的LSA腹水肿瘤细胞对阿糖胞苷的摄取。研究了细胞群去除后肿瘤摄取随衰老的变化以及用1000拉德对细胞群进行扰动后的情况。DNA合成和药物摄取在肿瘤早期快速生长期间最高，并随着衰老和生长静止期而降低。然而，辐照导致细胞活性和药物摄取出现第二个峰值。这些结果表明辐照刺激肿瘤再生。
