Juratsch C E, Emmanouilides G C, Thibeault D W, Baylen B G, Jengo J A, Laks M M
Pediatr Res. 1980 Dec;14(12):1332-8. doi: 10.1203/00006450-198012000-00012.
Distention of the main pulmonary artery by balloon inflation in sheep results in presumably reflex elevation of pulmonary arterial pressure and resistance distal to the balloon. This response to main pulmonary artery distention is significantly greater in newborn lambs than in older lambs or adult sheep. In several of the newborn lambs, pulmonary artery pressure was raised to suprasystemic levels. Further, in some of the newborn animals, these increases in pulmonary artery pressure and resistance were sustained after deflation of teh balloon for periods up to 2 hr. The functional significance of this pulmonary hypertension reflex was not elucidated. However, the data strongly suggest that this reflex may contribute to the maintenance of high pulmonary vascular resistance during fetal and early neonatal life.
在绵羊中通过球囊充气扩张主肺动脉会导致球囊远端的肺动脉压力和阻力出现推测性的反射性升高。新生羔羊对主肺动脉扩张的这种反应比年长羔羊或成年绵羊要大得多。在几只新生羔羊中，肺动脉压力升高到了体循环以上的水平。此外，在一些新生动物中，球囊放气后肺动脉压力和阻力的这些升高可持续长达2小时。这种肺动脉高压反射的功能意义尚未阐明。然而，这些数据强烈表明，这种反射可能有助于在胎儿期和新生儿早期维持高肺血管阻力。
