Baylen B G, Emmanouilides G C, Juratsch C E, Yoshida Y, French W J, Criley J M
J Pediatr. 1980 Mar;96(3 Pt 2):540-4. doi: 10.1016/s0022-3476(80)80863-8.
Balloon-induced distention of the main pulmonary artery causes acute pulmonary hypertension and reflex pulmonary vasoconstriction in animals. Pulmonary artery pressure responses caused by MPA balloon inflation were measured in ten human newborn infants with cardiac failure (n = 5) or persistent fetal circulation (n = 5). During balloon inflation distal mean PAP increased significantly while cardiac rate remained unchanged. MPA distention caused greater increases of PAP in those infants with lower resting PAP. The greatest balloon-induced increases of PAP were observed in infants recovering from PFC. The existence of a pulmonary artery reflex and its possible role in the regulation of the human fetal and neonatal pulmonary circulation is discussed.
球囊诱导的主肺动脉扩张可导致动物出现急性肺动脉高压和反射性肺血管收缩。对10例患有心力衰竭（n = 5）或持续性胎儿循环（n = 5）的人类新生儿，测量了主肺动脉球囊扩张引起的肺动脉压力反应。在球囊扩张过程中，远端平均肺动脉压显著升高，而心率保持不变。主肺动脉扩张在静息肺动脉压较低的婴儿中引起的肺动脉压升高幅度更大。在从持续性胎儿循环恢复的婴儿中观察到球囊诱导的肺动脉压最大升高。本文讨论了肺动脉反射的存在及其在人类胎儿和新生儿肺循环调节中的可能作用。
