Fredrikzon B, Bläckberg L
Pediatr Res. 1980 Dec;14(12):1387-90. doi: 10.1203/00006450-198012000-00026.
A convenient lipase assay that discriminates between pancreatic and lingual lipase activities was developed to describe some properties of the triglyceride-hydrolyzing activities of lingual lipase (from von Ebners glands) and pancreatic lipase. Secretion of lingual lipase is stimulated by feeding. Gastric contents collected postyprandially from patients with cystic fibrosis (CF) contained lipase activity which is probably secreted from pharyngeal tissues. Also, duodenal contents from CF patients contained lipase activity with properties very close to those found in gastric contents from CF patients and controls. Apparently, the serous glands responsible for the secretion of lingual lipase is less affected than the exocrine pancrease in this disease. During fat balance experiments, CF patients utilized around 40% of the dietary lipids and more than 50% of milk lipids given as a test meal were hydrolyzed in the duodenum within 2 hr. In these patients with severe pancreatic insufficiency, we suggest that the lingual lipase is responsible for a considerable proportion of triglyceride hydrolysis. This hydrolysis starts in the stomach and continues in duodenum.
我们开发了一种便捷的脂肪酶测定方法，该方法能够区分胰腺脂肪酶和舌脂肪酶的活性，以此来描述舌脂肪酶（来自埃伯纳腺）和胰腺脂肪酶的甘油三酯水解活性的一些特性。喂食可刺激舌脂肪酶的分泌。餐后从囊性纤维化（CF）患者收集的胃内容物含有脂肪酶活性，这可能是由咽部组织分泌的。此外，CF患者的十二指肠内容物含有脂肪酶活性，其特性与CF患者和对照组胃内容物中发现的特性非常接近。显然，在这种疾病中，负责分泌舌脂肪酶的浆液腺比胰腺外分泌腺受影响小。在脂肪平衡实验中，CF患者利用了约40%的膳食脂质，作为测试餐给予的超过50%的乳脂在2小时内在十二指肠中被水解。在这些严重胰腺功能不全的患者中，我们认为舌脂肪酶在相当大比例的甘油三酯水解中起作用。这种水解始于胃并在十二指肠中继续。
