Travis S F, Kumar S P, Delivoria-Papadopoulos M
Pediatr Res. 1981 Jan;15(1):34-7. doi: 10.1203/00006450-198101000-00008.
Red cell glycolytic intermediates and adenosinetriphosphate were evaluated in term infants from birth to on year of age and compared to values obtained from normal adults and subjects wit a population of a similar mean cell age. The concentration of glycolytic intermediates, with the exception of phosphoenolypyruvate were elevated at birth when compared to normal subjects, consistent with a young mean red cell population. The mean levels of red cell glucose-6-phosphate, fructose-6-phosphate, and "total triose phosphate" were elevated on days 1 and 4 of life when compared to both red cells from normal adults and subjects with a similar young mean red cell age. Glucose-6-phosphate steadily increased in concentration, peaked at 3 to 4 wk of age, and then progressively decreased in value. Total triose phosphate declined to a mildly elevated concentration by 3 to 4 wk of age. The mean concentrations of 2,3-diphosphoglycerate and adenosine triphosphate were normal on day 1, increased on day 4, and then declined by 3 to 4 wk to normal values, until 5 to 6 months when both increased. The mean phosphoenolpyruvate concentration was decreased on day 1 of age when compared to red cells of a similar mean age, but this decrease was not significant (P greater than 0.05). The mean concentrations of 3-phosphoglycerate increased at 3 to 4 wk of age and remained elevated for cell age at 11 to 12 months but this increase was no statistically significant (P greater than 0.05). 3-Phosphoglycerate levels did not change significantly throughout the first year of life. At one year of age, all red glycolytic intermediates and adenosine triphosphate were elevated when compared to red cells from normal adults, but were comparable to those observed in subjects with a red cell population of a similar mean cell age, consistent with the persistence of a young red cell population throughout the first year of life.
对足月儿从出生到1岁期间的红细胞糖酵解中间产物和三磷酸腺苷进行了评估，并与正常成年人以及平均细胞年龄相似的人群所获得的值进行了比较。与正常受试者相比，除磷酸烯醇式丙酮酸外，糖酵解中间产物的浓度在出生时升高，这与年轻的平均红细胞群体一致。与正常成年人的红细胞以及平均红细胞年龄相似的受试者相比，红细胞葡萄糖-6-磷酸、果糖-6-磷酸和“总磷酸丙糖”的平均水平在出生后第1天和第4天升高。葡萄糖-6-磷酸的浓度稳步增加，在3至4周龄时达到峰值，然后逐渐下降。总磷酸丙糖在3至4周龄时降至轻度升高的浓度。2,3-二磷酸甘油酸和三磷酸腺苷的平均浓度在第1天正常，在第4天升高，然后在3至4周时降至正常值，直到5至6个月时两者均升高。与平均年龄相似的红细胞相比，磷酸烯醇式丙酮酸的平均浓度在出生后第1天降低，但这种降低不显著（P大于0.05）。3-磷酸甘油酸的平均浓度在3至4周龄时升高，并在11至12个月时保持升高，但这种升高无统计学意义（P大于0.05）。在生命的第一年中，3-磷酸甘油酸水平没有显著变化。在1岁时，与正常成年人的红细胞相比，所有红细胞糖酵解中间产物和三磷酸腺苷均升高，但与平均细胞年龄相似的红细胞群体中观察到的值相当，这与年轻红细胞群体在生命的第一年中持续存在一致。
