Arnaud J, Gutierrez N
Am J Phys Anthropol. 1984 Mar;63(3):307-14. doi: 10.1002/ajpa.1330630307.
We have found that glycolysis in human red blood cells under the hypoxic conditions found at high altitudes is connected with changes in enzyme activities and levels of various metabolic intermediates. The sensitivity of the four kinases to hypoxia results in 1) glycolytic hyperactivity leading to a higher intracellular energy state, and 2) accumulation of 2-3 DPG, whose role in the adaptation of red blood cell respiration to high altitude has been shown by previous research. PEP, 3PG , and G6P appear to be the main regulating intermediates in glycolysis in this system. The reason for the very large increase in G1- 6DP is still not clear.
我们发现，在高海拔地区出现的低氧条件下，人类红细胞中的糖酵解与酶活性变化及各种代谢中间产物的水平有关。四种激酶对低氧的敏感性导致：1）糖酵解活性增强，从而使细胞内能量状态升高；2）2,3-二磷酸甘油酸（2,3-DPG）积累，先前的研究已表明其在红细胞呼吸适应高海拔环境中的作用。磷酸烯醇式丙酮酸（PEP）、3-磷酸甘油酸（3PG）和6-磷酸葡萄糖（G6P）似乎是该系统中糖酵解的主要调节中间产物。6-磷酸葡萄糖-1,6-二磷酸酯（G1-6DP）大幅增加的原因仍不清楚。
