Malakhova L V, Lil'p I G, Korogodina Iu V, Gaziev A I
Genetika. 1978 Nov;14(11):1996-2001.
The same damages were found to occur in hepatocyte DNA from old mice of different strains by means of sedimentation in alkaline sucrose concentration gradient. At the same time, the number of hepatocytes with aberrant chromosomes is strongly different in these strains. From these data an assumption is made that some other damages being accumulated with aging are responsible for chromosome aberrations except for single-strand DNA breaks. The number of single-strand breaks registered in hepatocyte DNA of the old animals under gamma-irradiation is two-three times more than that of the young animals, though the rates of repair of the induced single-strand breaks in DNA are the same for mice of different age and strains.
通过碱性蔗糖浓度梯度沉降法发现，不同品系的老年小鼠的肝细胞DNA中会出现相同的损伤。与此同时，这些品系中染色体异常的肝细胞数量差异很大。从这些数据可以假设，除了单链DNA断裂外，随着衰老积累的其他一些损伤是导致染色体畸变的原因。老年动物在γ射线照射下，肝细胞DNA中记录的单链断裂数量比年轻动物多两到三倍，尽管不同年龄和品系的小鼠DNA中诱导的单链断裂的修复速率是相同的。
