用于评估快速心血管药物效应的短寿命放射性核素。
Short-lived radionuclides for the assessment of rapid cardiovascular drug effects.
作者信息
Knapp W H, Helus F, Tillmanns H, Elfner R, Ostertag H, Kübler W
出版信息
Nuklearmedizin. 1980 Aug;19(4):161-5.
Continuous monitoring of cardiac output and sequential studies of right ventricular ejection fraction and of fractional myocardial uptake of substances with high cell affinity can be realized using 13N (t 1/2 = 9.6 min) and 81mKr (t 1/2 = 13 sec). Thus, it is possible to measure rapid changes of absolute myocardial blood flow and of the inotropic state of the right heart myocardium. This is shown in patients who underwent interventions with Dipyridamole and with Dobutamine which produce a marked increase in myocardial blood flow or cardiac dynamics, respectively.
使用(^{13}N)（半衰期(t_{1/2}=9.6)分钟）和(^{81m}Kr)（半衰期(t_{1/2}=13)秒）可以实现对心输出量的连续监测以及对右心室射血分数和具有高细胞亲和力物质的心肌摄取分数的系列研究。因此，有可能测量绝对心肌血流量和右心心肌收缩性状态的快速变化。这在接受潘生丁和多巴酚丁胺干预的患者中得到了体现，这两种药物分别使心肌血流量或心脏动力学显著增加。
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