Uziel A, Baldy-Moulinier M, Marot M, Abboudi C, Passouant P
Rev Electroencephalogr Neurophysiol Clin. 1980 Apr-Jun;10(2):153-60. doi: 10.1016/s0370-4475(80)80048-7.
Auditory brainstem potentials were recorded in 54 old adult subjects ranging in age from 61 to 89 years. Attention was paid to interwave latencies in order to assess the effects of aging on central conduction time. The data were compared to those obtained in 41 young adult subjects. Advancing age resulted in a slight-prolongation of I-III, III-V and I-V interpeak latencies when compared to young adult subjects (about 0.2 ms); nevertheless there were no statistical differences between the mean values of old and young subjects. Abnormalities of brainstem potentials were found in 30% of the old patients; i.e. interpeak latency prolongation and desynchronisation. Brainstem abnormalities were more likely to be found in patients with delta E.E.G. activity and criteria of deterioration at the psychometric tests. Lesser degrees of abnormalities (7%) were seen in old patients without any vascular or neurologic disorder, than in patients with one of those pathological processes (77%). The results suggest that brainstem potentials abnormalities observed in old subjects are not related to age as such, but to associated vascular or degenerative disorders, the frequency of which increases with age.
对54名年龄在61岁至89岁之间的老年受试者进行了听觉脑干电位记录。重点关注波间潜伏期,以评估衰老对中枢传导时间的影响。将这些数据与41名年轻成年受试者的数据进行了比较。与年轻成年受试者相比,年龄增长导致I-III、III-V和I-V峰间潜伏期略有延长(约0.2毫秒);然而,老年和年轻受试者的平均值之间没有统计学差异。30%的老年患者存在脑干电位异常;即峰间潜伏期延长和去同步化。在脑电图出现δ波活动且心理测量测试有恶化标准的患者中,更容易发现脑干异常。与患有血管或神经系统疾病之一的患者(77%)相比,没有任何血管或神经系统疾病的老年患者出现较轻程度异常的比例(7%)较低。结果表明,在老年受试者中观察到的脑干电位异常并非与年龄本身相关,而是与相关的血管或退行性疾病有关,这些疾病的发生率随年龄增长而增加。