Cooper W A, Coleman J R, Newton E H
Department of Communicative Disorders, University of South Carolina, Columbia 29208.
Hear Res. 1990 Jan;43(2-3):171-9. doi: 10.1016/0378-5955(90)90226-f.
The auditory brain stem response (ABR) was studied in young adult and aged rats using 3,8 and 40 kHz tone pips. The expected inverse relationship between frequency and latency was observed in the younger group for waves I, II and III, while the response to the highest frequency stimulus had the longest latency at wave V. Absolute latencies for waves I through V each showed age-related increments with more pronounced changes occurring to 3 and 40 kHz stimuli than to the frequency of maximum sensitivity (8 kHz). Threshold increases with age for the highest frequency approximately doubled those for the lower frequencies. Examination of interpeak intervals (IPI) I-III, III-V and I-V revealed aging effects. The largest IPI I-V increment occurred to 3 kHz stimulation which reflects changes at both I-III and III-V sub-intervals. These results demonstrate electrophysiological correlates of aging due to transformations in the peripheral auditory system coupled with alterations in brainstem auditory pathways.
使用3、8和40千赫兹的短纯音，对年轻成年大鼠和老年大鼠的听觉脑干反应（ABR）进行了研究。在较年轻的组中，对于波I、II和III，观察到了频率与潜伏期之间预期的反比关系，而在波V时，对最高频率刺激的反应具有最长的潜伏期。波I至V的绝对潜伏期均显示出与年龄相关的增加，与最大敏感性频率（8千赫兹）相比，3千赫兹和40千赫兹刺激出现的变化更为明显。最高频率的阈值随年龄增加，约为较低频率阈值增加的两倍。对峰间期（IPI）I-III、III-V和I-V的检查揭示了衰老效应。I-V峰间期的最大增加出现在3千赫兹刺激时，这反映了I-III和III-V子间期的变化。这些结果表明，由于外周听觉系统的转变以及脑干听觉通路的改变，衰老存在电生理相关性。
