Danieli G, Corvetta A, Mariuzzi G M, Beltrami C A, Osculati F, Cinti S, Massei V, Sanguinetti C M
Ric Clin Lab. 1980 Oct-Dec;10(4):597-608.
Clinical, physiological and histological investigations on lung involvement are reported in 33 rheumatoid patients. The clinico-pathological patterns of rheumatoid lung disease observed in 19/27 non-smoking female patients were characterized radiologically by diffuse interstitial opacities, functionally by V/Q inequality and microscopically by peribronchiolar and/or alveolar fibrosis. Emphasis is placed on the ventilation/perfusion relationship as well as histopathological studies for a more accurate diagnosis of lung disease in RA. Patients with pulmonary nodules and pleural opacities were also observed. A possible immunological aetiology is suggested on the basis of the simultaneous finding of IgG, complement and fibrinogen in the pulmonary tissue.
报告了对33例类风湿性关节炎患者肺部受累情况的临床、生理和组织学研究。在19/27例非吸烟女性患者中观察到的类风湿性肺病的临床病理模式，在放射学上表现为弥漫性间质模糊影，功能上表现为通气/血流比例失调，显微镜下表现为细支气管周围和/或肺泡纤维化。强调通气/血流关系以及组织病理学研究，以便更准确地诊断类风湿性关节炎中的肺部疾病。还观察到有肺结节和胸膜模糊影的患者。基于在肺组织中同时发现IgG、补体和纤维蛋白原，提示了一种可能的免疫病因。
