甲状腺功能正常、甲状腺功能减退和甲状腺功能亢进受试者的血清肌红蛋白、肌酸激酶、乳酸脱氢酶和心肌同工酶浓度。

Serum concentrations of myoglobin, creatine kinase, lactate dehydrogenase and cardiac isoenzymes in euthyroid, hypothyroid and hyperthyroid subjects.

作者信息

Roti E, Bandini P, Robuschi G, Emanuele R, Bolognesi R, Ciarlini E, Buzzonetti P, Gnudi A

出版信息

Ric Clin Lab. 1980 Oct-Dec;10(4):609-17. doi: 10.1007/BF02906700.

PMID:7209295

Abstract

Serum concentrations of myoglobin, creatine kinase and lactate dehydrogenase were measured in 33 euthyroid, 21 hyperthyroid and 15 hypothyroid subjects. The results showed that myoglobin, creatine kinase and lactate dehydrogenase were increased and decreased in the hypo- and hyperthyroid states, respectively. In addition, the concentrations of myoglobin, creatine kinase and lactate dehydrogenase values were inversely related to both the thyroxine and triiodothyronine concentrations. To study the origin of the increased muscle protein values observed in hypothyroidism, the cardiac isoenzyme fractions were measured; the results obtained support the view that the muscle enzymes are mainly derived from skeletal muscles.

摘要

在33名甲状腺功能正常、21名甲状腺功能亢进和15名甲状腺功能减退的受试者中测量了血清肌红蛋白、肌酸激酶和乳酸脱氢酶的浓度。结果表明，肌红蛋白、肌酸激酶和乳酸脱氢酶在甲状腺功能减退和亢进状态下分别升高和降低。此外，肌红蛋白、肌酸激酶和乳酸脱氢酶的值与甲状腺素和三碘甲状腺原氨酸的浓度呈负相关。为了研究甲状腺功能减退时观察到的肌肉蛋白值升高的来源，测量了心脏同工酶组分；所得结果支持肌肉酶主要来源于骨骼肌的观点。