Rudolph R, Utley J, Woodward M, Hurn I
Surg Gynecol Obstet. 1981 Feb;152(2):171-8.
Chronic radiation skin ulcers were produced in rats with the administration of 5,000 or 8,000 rads. Electron microscopy revealed two phases of damage, the first from seven to 14 weeks and the second from 14 to 54 weeks. In the first phase, significant nuclear and cytoplasmic degeneration was prominent. During the second phase, lysosomes were common along with unusual cytoplasmic inclusions. Myofibroblasts were observed in the second phase only, suggesting that delayed would contraction in radiation ulcers was the result of the delayed onset of myofibroblast development.
通过给予5000或8000拉德的辐射剂量在大鼠身上产生慢性放射性皮肤溃疡。电子显微镜检查揭示了两个损伤阶段，第一阶段为7至14周，第二阶段为14至54周。在第一阶段，明显的核和细胞质变性很突出。在第二阶段，溶酶体很常见，同时伴有异常的细胞质内含物。仅在第二阶段观察到肌成纤维细胞，这表明放射性溃疡中延迟的伤口收缩是肌成纤维细胞发育延迟开始的结果。
