Rudolph R, Arganese T, Woodward M
Ann Plast Surg. 1982 Oct;9(4):282-92. doi: 10.1097/00000637-198210000-00003.
Ulcerated and nonulcerated skin from 5 patients with chronic radiation skin damage was examined using electron microscopy. Noticeable fibroblast disorganization was seen, with swollen and degenerating mitochondria, multiple vacuoles, and dilated irregular rough endoplasmic reticulum. Unusual crystalline inclusions were seen in some fibroblasts. In the ulcerated skin, contractile fibroblasts (myofibroblasts) were seen in 2 of 4 specimens. Stroma showed dense collagen and prominent elastosis. The microvasculature in the radiation-damaged tissue showed occasional lumen occlusion and vacuolization of endothelial cells, without consistent abnormality. These data suggest that permanent damage to fibroblasts or fibroblast stem cells may play an important role in chronic radiation skin ulceration.
使用电子显微镜检查了5例慢性放射性皮肤损伤患者的溃疡性和非溃疡性皮肤。可见明显的成纤维细胞紊乱，线粒体肿胀、退化，有多个空泡，粗面内质网扩张且不规则。在一些成纤维细胞中可见异常的晶体包涵体。在溃疡性皮肤中，4个标本中有2个可见收缩性成纤维细胞（肌成纤维细胞）。间质显示致密的胶原和明显的弹性组织变性。放射性损伤组织中的微血管偶尔可见管腔闭塞和内皮细胞空泡化，但无一致的异常。这些数据表明，成纤维细胞或成纤维细胞干细胞的永久性损伤可能在慢性放射性皮肤溃疡形成中起重要作用。
