Lerman S H, Mason G R, Bathon E M, Ormsbee H S
Surgery. 1981 Apr;89(4):460-5.
Through this study we evaluated the effect of electrical stimulation of the greater splanchnic nerve on gastroduodenal motility in anesthetized dogs. The majority of stimulations (at a frequency of 10 Hz for 5 msec at a strength of 10V for a train of 10 sec) produced contractions in the gastric antrum and pylorus and relaxation in the duodenum. The antral, pyloric, and duodenal motor responses were unaffected by cervical vagosympathectomy, thoracic vagotomy, and adrenalectomy. Administration of phentolamine, propranolol, or hexamethonium and pretreatment with reserpine failed to affect the contractile gastroduodenal motor response. The inhibitory motor response in the duodenum was also unaffected by these surgical procedures and administration of drugs. After atropine administration, contractions induced by splanchnic nerve stimulation were abolished in the pylorus, as well as in the antrum and duodenum. Tetrodotoxin also abolished the gastroduodenal motor response. The greater splanchnic nerve contains an excitatory cholinergic pathway to the musculature of the pylorus.
通过本研究，我们评估了电刺激内脏大神经对麻醉犬胃十二指肠运动的影响。大多数刺激（频率为10Hz，强度为10V，持续5毫秒，共10秒的一串刺激）可使胃窦和幽门收缩，十二指肠松弛。胃窦、幽门和十二指肠的运动反应不受颈迷走交感神经切除术、胸段迷走神经切断术和肾上腺切除术的影响。给予酚妥拉明、普萘洛尔或六甲铵以及用利血平预处理均未能影响胃十二指肠的收缩性运动反应。十二指肠的抑制性运动反应也不受这些外科手术和药物给药的影响。给予阿托品后，内脏大神经刺激诱导的幽门以及胃窦和十二指肠的收缩被消除。河豚毒素也消除了胃十二指肠的运动反应。内脏大神经包含一条通向幽门肌肉组织的兴奋性胆碱能通路。
