Müller-Lissner S A, Fimmel C J, Sonnenberg A, Will N, Müller-Duysing W, Heinzel F, Müller R, Blum A L
Gut. 1983 Jun;24(6):510-8. doi: 10.1136/gut.24.6.510.
A new method is described which allows simultaneous measurement of gastric emptying and duodenogastric reflux and avoids transpyloric intubation. After intragastric instillation of a liquid lipid meal in six healthy volunteers the fractional gastric emptying rate was 2.9 +/- 0.3 in the upright and 2.5 +/- 0.6 SEM X 10(-2)/min in the supine position, respectively (p greater than 0.5). The duodenogastric reflux rate (expressed as fraction of the intraduodenal amount of duodenal marker) was 0.30 (range 0.03-0.81) and 0.22 (0.01-0.55) X 10(-2)/min, respectively (p greater than 0.2). Atropine (40 micrograms/kg) decreased the supine gastric emptying rate to 1.1 +/- 0.2 (p less than 0.05) and increased the supine duodenogastric reflux rate to 2.74 (0.04-9.80) X 10(-2)/min (p less than 0.05). Fasting duodenogastric reflux rate was similar in the supine and upright position, 0.49 (0.04-0.89) and 0.42 (0.06-0.97) X 10(-2)/min, respectively (p greater than 0.5). Fractional gastric emptying rate was similar in 10 volunteers and 17 patients with type I gastric ulcer (2.1 +/- 0.4 vs 1.7 +/- 0.2 SEM X 10(-2)/min, p greater than 0.2). Their duodenogastric reflux rates were also similar, 0.65 (0.01-5.24) vs 1.10 (0.01-10.83) X 10(-2)/min (p greater than 0.5). We conclude therefore that (1) gastric emptying and both fasting and postprandial duodenogastric reflux are independent of the posture; (2) fasting and postprandial reflux are of similar magnitude; (3) atropine shows gastric emptying and increases duodenogastric reflux; and (4) patients with type I gastric ulcer have neither slowed gastric emptying nor increased duodenogastric reflux.
本文描述了一种新方法，该方法可同时测量胃排空和十二指肠-胃反流，且无需经幽门插管。在6名健康志愿者胃内注入液态脂质餐后，立位时胃排空分数率为2.9±0.3×10⁻²/分钟，卧位时为2.5±0.6 SEM×10⁻²/分钟（p＞0.5）。十二指肠-胃反流率（以十二指肠标记物在十二指肠内的量的分数表示）分别为0.30（范围0.03 - 0.81）和0.22（0.01 - 0.55）×10⁻²/分钟（p＞0.2）。阿托品（40微克/千克）使卧位胃排空率降至1.1±0.2（p＜0.05），并使卧位十二指肠-胃反流率增至2.74（0.04 - 9.80）×10⁻²/分钟（p＜0.05）。空腹时，卧位和立位的十二指肠-胃反流率相似，分别为0.49（0.04 - 0.89）和0.42（0.06 - 0.97）×10⁻²/分钟（p＞0.5）。10名志愿者和17名I型胃溃疡患者的胃排空分数率相似（2.1±0.4对1.7±0.2 SEM×10⁻²/分钟，p＞0.2）。他们的十二指肠-胃反流率也相似，分别为0.65（0.01 - 5.24）和1.10（0.01 - 10.83）×10⁻²/分钟（p＞0.5）。因此，我们得出结论：（1）胃排空以及空腹和餐后十二指肠-胃反流均与体位无关；（2）空腹和餐后反流程度相似；（3）阿托品减慢胃排空并增加十二指肠-胃反流；（4）I型胃溃疡患者既没有胃排空减慢，也没有十二指肠-胃反流增加。
