Kraft-Kinz J, Rigler B
Herz. 1978 Feb;3(1):49-54.
Congenital heart lesions are found in 0.8% of all newborns; four-fifths of them are correctable. Two thirds of all surgical procedures are done in acyanotic malformations, mainly in septal defects, patent ductus arteriosus, coarctations of the aorta and valvular stenosis. Within the last twenty years corrective repair has been established with good results in these lesions. Therapeutic problems still remain in cases of late diagnosis and in some rare and complex anomalies like malformations of the aortic arch, of the coronary arteries, in some types of aortopulmonary window and atrioventricular canal. Surgery becomes urgent in babies suffering from severe heart disease because of progressive pulmonary hypertension, inadequate growth or severe heart failure (despite intensive medical treatment). For certain lesions corrective repair (patent ductus arteriosus, coarctation) is definitely indicated, for others (ventricular septal defect, atrioventricular canal) urgent palliation or early total repair is debatable. In most patients with uncomplicated lesions treated in time during childhood a low operative mortality below 1% was observed. A higher mortality rate was found (10 to 50%) in patients with pulmonary artery disease or associated pulmonary lesions. A significantly higher mortality could also be observed in the advanced age group (4.7%) and in infants below one year of age (11,5%), underlining the important point of the age at operations. Recurrence of lesions occured in 1% of our patients after closure of ventricular septal defects, reconstructions of mitral valve disease and early corrected coarctations. Nevertheless, most of these patients can expect a normal growth, life span and ability to work.
先天性心脏病变在所有新生儿中的发生率为0.8%;其中五分之四是可以矫正的。所有外科手术的三分之二是针对无青紫型畸形进行的,主要是室间隔缺损、动脉导管未闭、主动脉缩窄和瓣膜狭窄。在过去的二十年里,针对这些病变的矫正修复已取得良好效果。对于晚期诊断的病例以及一些罕见和复杂的异常情况,如主动脉弓畸形、冠状动脉畸形、某些类型的主肺动脉窗和房室通道,治疗问题仍然存在。由于进行性肺动脉高压、生长发育不良或严重心力衰竭(尽管进行了强化药物治疗),患有严重心脏病的婴儿手术变得紧急。对于某些病变(动脉导管未闭、主动脉缩窄)明确需要进行矫正修复,而对于其他病变(室间隔缺损、房室通道),紧急姑息治疗或早期完全修复存在争议。在大多数儿童期及时治疗的无并发症病变患者中,观察到手术死亡率低于1%。在患有肺动脉疾病或相关肺部病变的患者中,发现死亡率较高(10%至50%)。在高龄组(4.7%)和一岁以下婴儿(11.5%)中也观察到明显较高的死亡率,突出了手术年龄这一要点。在我们的患者中,室间隔缺损闭合、二尖瓣疾病重建和早期矫正主动脉缩窄后,1%的患者出现病变复发。然而,这些患者中的大多数有望正常生长、拥有正常寿命和工作能力。