Chinouth R W, Czajka P A, Peterson R G
Vet Hum Toxicol. 1980 Dec;22(6):392-4.
N-acetylcysteine was adsorbed by activated charcoal, lending in vitro support to previous clinical of activated charcoal for NAC in biologic fluid was significantly greater than in nonbiologic fluid and has important clinical implications. Although some have advocated lavage to remove activated charcoal prior to the administration of NAC, the avid adsorption of NAC suggested that activated charcoal may not be justifiable for acetaminophen overdosage when NAC therapy is indicated. Studies in humans are required to substantiate the clinical significance of this in vitro adsorption.
N-乙酰半胱氨酸被活性炭吸附，这为之前关于活性炭在生物流体中对N-乙酰半胱氨酸吸附作用的临床研究提供了体外支持，活性炭在生物流体中的吸附显著大于在非生物流体中的吸附，具有重要的临床意义。尽管一些人主张在给予N-乙酰半胱氨酸之前进行洗胃以清除活性炭，但N-乙酰半胱氨酸的强烈吸附表明，当需要进行N-乙酰半胱氨酸治疗时，活性炭对于对乙酰氨基酚过量可能不合理。需要在人体进行研究以证实这种体外吸附的临床意义。
