Rybolt T R, Burrell D E, Shults J M, Kelley A K
J Pharm Sci. 1986 Sep;75(9):904-6. doi: 10.1002/jps.2600750918.
The in vitro adsorption and coadsorption of acetaminophen and N-acetylcysteine using simulated gastric (pH 1.2) and intestinal (pH 7.0) conditions were examined for a range of charcoal-to-drug ratios between 1 and 7. Although both substances were adsorbed by the activated carbon, the adsorption of acetaminophen was greater than that of N-acetylcysteine for both acidic and neutral pH conditions. In the coadsorption studies, the acetaminophen was always adsorbed to a greater extent than the N-acetylcysteine. These results agree with previous in vivo studies that suggest that the concomitant use of N-acetylcysteine and activated carbon powder is an appropriate treatment for acetaminophen overdose.
在模拟胃液（pH 1.2）和肠液（pH 7.0）条件下，研究了对乙酰氨基酚和N - 乙酰半胱氨酸在炭与药物比例为1至7范围内的体外吸附及共吸附情况。尽管两种物质均被活性炭吸附，但在酸性和中性pH条件下，对乙酰氨基酚的吸附量均大于N - 乙酰半胱氨酸。在共吸附研究中，对乙酰氨基酚的吸附程度始终高于N - 乙酰半胱氨酸。这些结果与先前的体内研究一致，表明N - 乙酰半胱氨酸和活性炭粉联合使用是对乙酰氨基酚过量的合适治疗方法。
