Toda T, Leszczynski D, McGibbon W H, Kummerow F A
Virchows Arch A Pathol Anat Histol. 1980;388(2):123-35. doi: 10.1007/BF00430682.
The effects of hereditary hyperlipidemia on coronary artery atherosclerosis were studied in 77 White Leghorn (DeKalb strain) chickens ranging from 4 to 13 months in age. After pubescence, the plasma levels of triglyceride and cholesterol in non-laying hens ranged 2- to 3-fold and 2- to 7-fold higher compared to layers. Serial sectioning revealed that most lesions were found in the proximal portions of both the left and right coronary arteries. Ultrastructurally, lesions in the roosters contained no foam cells, whereas some foam cells and small amounts of stainable lipid were observed in the thickened intima of layers. Half of the non-layers had stenotic lesions characterized by many foam cells, necrotic foci, and heavy stromal lipid deposits. Continuous permeation of excess plasma lipids into the arterial wall appeared to be an important factor in the development of coronary lesions.
对77只4至13月龄的白来航（迪卡布品系）鸡进行研究，以探讨遗传性高脂血症对冠状动脉粥样硬化的影响。青春期后，与产蛋母鸡相比，不产蛋母鸡的血浆甘油三酯和胆固醇水平分别高出2至3倍和2至7倍。连续切片显示，大多数病变位于左、右冠状动脉近端。超微结构上，公鸡的病变中没有泡沫细胞，而在产蛋母鸡增厚的内膜中观察到一些泡沫细胞和少量可染色脂质。一半的不产蛋母鸡有狭窄性病变，其特征为有许多泡沫细胞、坏死灶和大量基质脂质沉积。过量血浆脂质持续渗入动脉壁似乎是冠状动脉病变发展的一个重要因素。
