Nandan R, Fisher J D, Towery E P, Brown D R, Ganote E, Jennings R B
Atherosclerosis. 1975 Sep-Oct;22(2):299-311. doi: 10.1016/0021-9150(75)90011-8.
Beagle dogs, 24 +/- 6 months old, fed a thiouracil-free semi-synthetic diet containing hydrogenated coconut oil and cholesterol (SS diet) for 12 months, developed marked hyperlipidemia and severe atherosclerosis. SS diet produced a marked elevation of serum cholesterol, triglyceride, phospholipid, and beta-lipoprotein and severe atherosclerosis in large and small arteries. Intimal fatty lesions were always present in the abdominal aorta and many of its branches. Large and small coronary arteries showed similar lesions. The degree of atherosclerosis was directly related to circulating lipid levels. Dextrothyroxine, at dose levels of 0.1 (equivalent to normal human dose) and 0.5 mg/kg body weight, produced a significant dose related lowering of serum lipids and was associated with a markedly decreased severity of aortic and coronary artery lesions. Untreated control dogs that were maintained on purina dog meal developed neither hyperlipidemia nor atherosclerosis.
24±6月龄的比格犬，喂食含氢化椰子油和胆固醇的无硫脲半合成饮食（SS饮食）12个月后，出现明显的高脂血症和严重的动脉粥样硬化。SS饮食使血清胆固醇、甘油三酯、磷脂和β-脂蛋白显著升高，并在大小动脉中引发严重的动脉粥样硬化。腹主动脉及其许多分支总是存在内膜脂肪病变。大小冠状动脉也出现类似病变。动脉粥样硬化的程度与循环脂质水平直接相关。剂量为0.1（相当于正常人类剂量）和0.5mg/kg体重的右旋甲状腺素可显著降低血脂，且主动脉和冠状动脉病变的严重程度明显降低。以普瑞纳犬粮维持喂养的未治疗对照犬既未出现高脂血症也未出现动脉粥样硬化。
