Yust I, Radiano C, Tartakovsky B, Tanay A, Shanon E, Segal S
Acta Otolaryngol. 1980 Nov-Dec;90(5-6):398-403. doi: 10.3109/00016488009131741.
Immunological studies were performed on 4 elderly diabetic patients with Malignant External Otitis caused by Pseudomonas aeruginosa. Impairment of cellular immunity was found. Skin tests for delayed hypersensitivity to PPD, SK-SD and Mumps antigen were negative and stimulation rates of peripheral blood lymphocytes by PHA, Con-A and PWM were depressed in all 4 patients. Serum immunoglobulins and complement levels were normal except in one case in which paraprotein IgG was found. Peripheral blood lymphoid cell markers and the neutrophil nitroblue tetrazolium (NBT) test were within normal limits in the 2 patients tested. These results indicate that cellular immune deficiency predisposes to the development of Malignant External Otitis in elderly diabetic patients.
对4例由铜绿假单胞菌引起的老年恶性外耳道炎糖尿病患者进行了免疫学研究。发现细胞免疫受损。所有4例患者对PPD、SK-SD和腮腺炎抗原的迟发型超敏皮肤试验均为阴性，PHA、Con-A和PWM对外周血淋巴细胞的刺激率降低。除1例发现副蛋白IgG外，血清免疫球蛋白和补体水平正常。2例受试患者的外周血淋巴细胞标志物和中性粒细胞硝基蓝四氮唑（NBT）试验均在正常范围内。这些结果表明，细胞免疫缺陷易导致老年糖尿病患者发生恶性外耳道炎。
