人类淋巴细胞的迁移。I. 以小鼠为宿主的模型。
Migration of human lymphocytes. I. A model using the mouse as host.
作者信息
Morgan K, Holt P J
出版信息
Immunology. 1978 Nov;35(5):695-705.
The distribution of radioactivity after the intravenous injection of 51Cr-labelled human lymphocytes has been examined in normal mice, irradiated mice, mice treated with anti-platelet antiserum and in mice treated with colloidal carbon. Pre-treatment with carbon and anti-platelet antiserum appears to protect the human lymphocytes from uptake by the host's reticuloendothelial system (RES). Comparison of tissue radioactivity in carbon-treated mice after the injection of viable human lymphocytes with that found after the injection of dead cells and soluble or insoluble cell debris showed that radioactivity recovered in the spleen and lymph nodes is primarily due to the migration of viable lymphocytes into these tissues. Thus the measurement of radioactivity in lymph nodes of carbon-treated mice after the injection of 51Cr-labelled human lymphocytes can be used as a model of these lymphocytes' ability to migrate into the lymph nodes during recirculation and to study factors influencing this migration.
已在正常小鼠、受辐照小鼠、用抗血小板抗血清处理的小鼠以及用胶体碳处理的小鼠中检测了静脉注射51Cr标记的人淋巴细胞后的放射性分布。用碳和抗血小板抗血清进行预处理似乎能保护人淋巴细胞不被宿主的网状内皮系统（RES）摄取。将注射活的人淋巴细胞后碳处理小鼠的组织放射性与注射死细胞以及可溶性或不溶性细胞碎片后发现的组织放射性进行比较，结果表明，脾脏和淋巴结中恢复的放射性主要是由于活淋巴细胞迁移到了这些组织中。因此，注射51Cr标记的人淋巴细胞后，测量碳处理小鼠淋巴结中的放射性，可作为这些淋巴细胞在再循环过程中迁移到淋巴结的能力的模型，并用于研究影响这种迁移的因素。
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