Hartzler G O, Holmes D R, Osborn M J
Am J Cardiol. 1981 Apr;47(4):903-9. doi: 10.1016/0002-9149(81)90192-2.
Recurrent, drug-refractory sustained tachycardias present a difficult management problem. After invasive electrophysiologic study and extensive antiarrhythmic drug testing, a permanent transvenous lead system and radiofrequency stimulator that required patient activation for burst pacing were implanted in eight patients with refractory ventricular tachycardia. In a follow-up period of 2 to 28.5 months (mean 12) each patient has successfully terminated multiple episodes of recurrent tachycardia without complication. This therapeutic approach has allowed a reduction in antiarrhythmic drug dosage and adverse effects, has obviated the need for frequent hospital admissions resulting from recurrent tachycardia, and has met with excellent patient acceptance.
复发性、药物难治性持续性心动过速带来了棘手的治疗难题。在进行有创电生理研究及广泛的抗心律失常药物测试后,为8例难治性室性心动过速患者植入了永久性经静脉导联系统及需患者激活以进行短阵起搏的射频刺激器。在2至28.5个月(平均12个月)的随访期内,每位患者均成功终止了多次复发性心动过速发作,且无并发症。这种治疗方法减少了抗心律失常药物的剂量及不良反应,避免了因复发性心动过速而频繁住院的需求,并且患者接受度良好。