Green T P, Thompson T R, Johnson D, Lock J E
Am J Dis Child. 1981 Mar;135(3):239-43. doi: 10.1001/archpedi.1981.02130270031011.
Furosemide is a known stimulant of the renal release of prostaglandin E2, a potent dilator of the ductus arteriosus. A possible relationship between furosemide use in infants with respiratory distress syndrome (RDS) and the incidence of patent ductus arteriosus (PDA) was investigated using two different retrospective analyses. The amount of furosemide administered prior to the day a murmur was heard in the infants with PDA was higher than the amount given to patients without PDA during the same period. In a historical analysis of patients treated for RDS in the years 1970 through 1979, furosemide use and fluid intake appeared to be independent factors contributing to the incidence of PDA. The proposed relationship between furosemide use and the occurrence of PDA in patients with RDS warrants further study.
呋塞米是一种已知的可刺激肾脏释放前列腺素E2的药物，前列腺素E2是动脉导管的强效扩张剂。我们使用两种不同的回顾性分析方法，对呋塞米在患有呼吸窘迫综合征（RDS）的婴儿中的使用与动脉导管未闭（PDA）发生率之间的可能关系进行了研究。在患有PDA的婴儿中，在听到杂音之日前给予的呋塞米剂量高于同期未患PDA的患者所给予的剂量。在对1970年至1979年期间接受RDS治疗的患者进行的历史分析中，呋塞米的使用和液体摄入量似乎是导致PDA发生率的独立因素。呋塞米的使用与RDS患者中PDA发生之间的这种推测关系值得进一步研究。
